I've done it, I've seen it all!
He's a fish out of water, he's a doctor is a small town village... that could describe a lot of series, but in this case it is Doc Martin, starring Martin Clunes. Who is kinda based on the character in the two tv movies, which was based on the character from the even earlier tv movie... but they couldn't spin up a tv series with that character (who is far too chill) and made him more uptight.
This is ten seasons, however as this is British tv, these are around eight episodes per, which the US wouldn't hit for several years. Often at the end of each season he is no longer able to be the village doctor... and then in the next season they work out how he can doctor again. Also I watched the beginning of each season wondering who came back. There was a big break after four seasons where several main characters don't return, so they quickly slot some other characters into those positions. (Oh, he gets another inexperienced secretary... oh, he has another aunt!)
There is definite character change, but more to the other characters than him. He does get married and has children, but still remains uptight and outspoken and with a bloodphobia (although the last episode quickly tries to pivot that to something else).
With Martin Clunes we get Ian McNeice, Stephanie Cole, and Katherine Parkinson (who is competent with computers... what?). Aside from those known, we get Caroline Catz, Joe Absolom, Selina Cadell, John Marquez, Jessica Random, and who turns out to be the absolutely lovely Eileen Atkins. And cameos from Ben Miller, Jeff Rawle, Chris O'Dowd, Louise Jameson, Caroline Quentin, Sigourney Weaver (!), and Rupert Graves, amongst others.
The reason I went into this is because there is now a US reboot, Best Medicine. The pilot episode is pretty much the same. There are different stories in there, but again some borrowed plots (such as one involving the doctor's father... who is played here by Martin Clunes!). But because this is a tv series in this current year, it's just ten episodes. Ah well, something else they got from the UK!
A fun wee series, ends on a Christmas episode. Definitely rewatchable!